University of Wisconsin–Madison

Publications

|

  1. Gowda AM, Rogers HT, Ríos Pérez EB, Ponce-Balbuena D, Shenkenberg SL, Ge Y, Alvarado FJ. Loss of phospholamban phosphorylation blunts Ca2+ handling during the cellular adrenergic response. J Mol Cel Cardiol 2026;7:20-25. PMID: 42106055. Read here!
  2. Pattridge HK, Ponce-Balbuena D, Ríos Pérez EB, Eckhardt LL, Valdivia HH, Alvarado FJ. Loss-of-Function Mutation RyR2-A4860G Confers an Arrhythmia Phenotype in Mice Inconsistent With Calcium Release Deficiency Syndrome. Circ Arrhythm Electrophysiol 2026;19:e014337. PMID: 41473951. Read here!
  3. Zheng J, Ponce-Balbuena D, Ríos Pérez EB, Xiao L, Dooge HC, Valdivia HH, Alvarado FJ. Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current. Nat Cardiovasc Res 2025;4:976-990. PMID: 40797044. Read here!
  4. Zheng J, Dooge HC, Perez-Hernandez M, Zhao YT, Chen X, Hernandez JJ, Valdivia CR, Palomeque J, Rothenberg E, Delmar M, Valdivia HH, Alvarado FJ. Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression. J Mol Cel Cardiol 2022;167:118-28. PMID: 35413295. Read here!

  1. Pattridge HK, Ponce-Balbuena D, Ríos Pérez EB, Eckhardt LL, Valdivia HH, Alvarado FJ. Loss-of-Function Mutation RyR2-A4860G Confers an Arrhythmia Phenotype in Mice Inconsistent With Calcium Release Deficiency Syndrome. Circ Arrhythm Electrophysiol 2026;19:e014337. PMID: 41473951.
  2. Gowda AM, Rogers HT, Ríos Pérez EB, Ponce-Balbuena D, Shenkenberg SL, Ge Y, Alvarado FJ. Loss of phospholamban phosphorylation blunts Ca2+ handling during the cellular adrenergic response. J Mol Cel Cardiol 2026;7:20-25. PMID: 42106055. Read here!

  1. Chapman EA, Rogers HT, Gao Z, Chan HJ, Alvarado FJ, Ge Y. In-depth characterization of S-glutathionylation in ventricular myosin light chain 1 across species by top-down proteomics. J Mol Cell Cardiol 2025;203:1-6. PMID: 40169117.
  2. Wexler AC, Dooge H, Serban L, Tewari A, Tehrani BM, Alvarado FJ, Ramratnam M. Pharmacologic ROMK inhibition protects against myocardial ischemia reperfusion injury. Int J Mol Sci 2025;26:3795. PMID: 40332433.
  3. Zheng J, Ponce-Balbuena D, Ríos Pérez EB, Xiao L, Dooge HC, Valdivia HH, Alvarado FJ. Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current. Nat Cardiovasc Res 2025;4:976-990. PMID: 40797044.
  4. Alvarado FJ, Ríos Pérez EB. Advances that position intracellular calcium dysregulation as an emerging therapeutic target in heart disease. Heart Rhythm 2025;22:2444-2445. PMID: 40912883.

  1. Wexler AC, Dooge H, El-Meanawy S, Santos EA, Tewari A, Hacker T, Alvarado FJ, Ramratnam M. Cardiac overexpression of a mitochondrial SUR2A splice variant impairs cardiac function and worsens myocardial ischemia reperfusion injury in female mice. JMCC Plus 2024;9:100088. PMID: 39507427.
  2. Janicek R, Camors EM, Potenza DM, Fernandez-Tenorio M, Zhao Y, Dooge H, Loaiza R, Alvarado FJ, Egger M, Valdivia HH, Niggli E. Dual ablation of the RyR2-S2808 and RyR2-S2814 sites increases propensity for pro-arrhythmic spontaneous Ca2+ releases. J Physiol 2024;602:5179-5201. PMID: 39316734.
  3. Rosas PC, Neves LAA, Patel N, Tran D, Pereira CH, Bonilla KR, Zheng J, Sun J, Alvarado FJ, Banach K. Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol 2024;327:H1524-H1543. PMID: 39485297.
  4. Ríos-Pérez EB, Alvarado FJ. Calpain inhibition takes center stage against atrial fibrillation in the diabetic heart. Heart Rhythm 2024;21:1152-1153. PMID: 38490602.

  1. El-Meanawy S, Dooge H, Kosmach AC, Serban L, Santos EA, Alvarado FJ, Hacker TA, Ramratnam M. Overexpression of a short sulfonylurea splice variant increases cardiac glucose uptake and uncouples mitochondria by regulating ROMK activity. Life (Basel) 2023;13:1015. PMID: 37109544.
  2. Cholak S, Saville, JW, Zhu X, Berezuk AM, Tuttle KS, Haji-Ghassemi O, Alvarado FJ, Van Petegem F, Subramaniam S. Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure 2023;31:790-800. PMID: 37192614.
  3. Medvedev RY, Turner DGP, DeGuire FC, Lang D, Alvarado FJ, Bondarenko VE, Gorelik J, Glukhov AV. Caveolae-associated cAMP/Ca2+-mediated mechano-chemical signal transduction in mouse atrial myocytes. J Mol Cel Cardiol 2023;184:75-85. PMID: 37805125.
  4. Waddell HMM, Mereacre V, Alvarado FJ, Munro ML. Clustering properties of the cardiac ryanodine receptor in health and heart failure. J Mol Cell Cardiol 2023;185:38-49. PMID: 37890552.

  1. Zheng J, Dooge HC, Perez-Hernandez M, Zhao YT, Chen X, Hernandez JJ, Valdivia CR, Palomeque J, Rothenberg E, Delmar M, Valdivia HH, Alvarado FJ. Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression. J Mol Cel Cardiol 2022;167:118-28. PMID: 35413295.

My NBCI Bibliography

Google Scholar

ORCiD